33 Studies have shown that agmatine derived from gut bacteria triggers inflammation and promotes the occurrence of colorectal tumors by activating the Wnt signaling pathway.34 Agmatine has recently been associated with Bacteroidetes and can act as an FXR agonist to promote polycystic ovarian syndrome in female mice.35 We observed that agmatine concentrations in normal human fecal samples ranged from 0.13 to 275 ng/mL, whereas in fecal samples from patients with CRC, the agmatine concentration was as high as 1,718 ng/mL. This evidence concerns the gene NR1H4 and colorectal neoplasm.