Several signalling pathways were also enriched in this as follows: MAPK signalling pathway (oocyte meiosis (hsa04114), progesterone mediated oocyte maturation (hsa04914), Osteoclast differentiation (hsa04380) and cell cycle (hsa04110), PI3K-Akt, NF-kB and JAK-STAT signalling pathways in Osteoclast differentiation (hsa04380), TGF-β and JAK-STAT signalling pathway in Inflammatory bowel disease (hsa05321) and Chemokine signalling pathway (hsa04062). This evidence concerns the gene TGFB1 and inflammatory bowel disease.