As there are only limited MRD monitoring markers for the AML-NK patients, such as NPM1 and FLT3-ITD mutations, overexpression of the oncogenes (FLT3, MYB, DNMT3B, and MYCN) can be useful in MRD monitoring, especially in cases with no genetic aberrations. Here, DNMT3B is linked to acute myeloid leukemia.