NPC1 and nasopharyngeal carcinoma: Because lack of NPC1 induces the hyperactivation of the metabolic regulator mTORC1 [8], and hyperactivation of mTORC1 in mouse microglia in vivo leads to an ameboid shape morphology, increased proliferation, and phagocytic activity [12], we sought to determine the involvement of mTORC1 in NPC microglia pathology.