PLG and cerebral amyloid angiopathy: Such clots aremore resistant to plasmin-mediated degradation, which can promoteinflammation. Furthermore, Aβ42and fibrin coaccumulate in cerebral vessels in patients with Alzheimer’sdisease, contributing to cerebral amyloid angiopathy, though Aβ40 is the predominant isoform. Given that bFg is a homologue of hFg, its potentialfor similar clot formation necessitates careful consideration in itstherapeutic application.