MAPT and Alzheimer disease: Recent studies have shown that human neural stem cells (hNSCs), integrated into 3D cell- or non-cell-autonomous culture systems for AD modeling, develop key representative features of AD neuropathology, including beta-amyloid aggregation, phosphorylated tau accumulation, and neuroinflammatory activity (Hebisch et al. 2023; Kwak et al. 2020; Papadimitriou et al. 2018; Park et al. 2018).