PAXIP1 and Anxiety: Conversely, anxiety‐like behavior in the EPM and spatial navigation assessed by the Barnes Maze are more dependent on amygdala‐ and hippocampal‐mediated pathways, respectively,[52, 53, 54] and thus may be less directly impacted by PFC‐specific dysregulation of PAXIP1‐AS1, or potentially compensated by other intact circuits.