Promotion of AKI by cisplatin occurs via the upregulation of apurinic/apyrimidinic endonuclease 2 (APE2), resulting in subsequent dysfunction of myosin heavy-chain 9 (MYH9) in the mitochondria of proximal tubule cells due to an additional role of APE2 in DDR [97]. Here, APEX2 is linked to acute kidney injury.