Furthermore, their research team unveiled a reciprocal regulatory relationship between the aryl hydrocarbon receptor (AhR) and the methyltransferase enhancer of zeste homolog 2 (EZH2) in the kidneys of mice with cisplatin-induced AKI or in murine renal tubular epithelial TCMK-1 cells, accelerating tubular senescence in the context of cisplatin-induced AKI [171]. Here, EZH2 is linked to acute kidney injury.