In preclinical models, inhibition of TLR7 or dual inhibition of TLR7/8 has been shown to ameliorate lupus nephritis in lupus-prone strains such as the New Zealand Black/New Zealand White F1 mice (NZBWF1 mice) and MRL/lpr mice (14–17). Here, TLR7 is linked to systemic lupus erythematosus.