These findings were corroborated by immunoblot assays, which revealed that hearts from pigs co‐treated with RD and Exos displayed the highest expression of Oct4, Klf4, Nanog and Gata4 but the lowest expression of LEF1 and Axin2 (Figure S7F), suggesting a reprogramming state in HF hearts following RD+Exos treatment. Here, KLF4 is linked to hydrops fetalis.