Growth factors and pro-inflammatory cytokines involved in myocardial fibrosis include connective tissue growth factor (CTGF), tissue growth factor-β (TGF-β), tumour necrosis factor-α (TNF-α), interleukin-11 (IL-11) and galectin-3 (Gal-3). The gene discussed is CCN2; the disease is Myocardial fibrosis.