It is noteworthy that the findings are consistent with those obtained in more severe disease (68, 69) (Supplementary Table S2): CRP/lymphocytes improved with isotonic SNI if early initiated in ARDS patients (68), while remained unaffected with inhalation of SNI 5% in treatment-refractory ventilated patients, albeit other parameters appeared to improve (69). Here, CRP is linked to acute respiratory distress syndrome.