↓ Mucosal response (innate and acquired immune parameters)↓ NK cell/neutrophil function↓ lymphocyte function↓ salivary IgA↓ MHC II expression in macrophages↓ cytotoxic T cells (over years of intensified training)↓ immune function↑ Leukocyte frequency (↑ in beginning, then ↓)↓ cytokine production↑ identification and eradication of tumor cells↑ reverse T cell immunosenescence (apoptosis of old T cells). The gene discussed is CD79A; the disease is neoplasm.