Moreover, a recent study by Rout-Pitt et al. (Rout-Pitt et al., 2025), which investigated EMT processes in CF rat models carrying either p.Phe508del- (class II) or a CFTR-KO (mimicking class I mutations), also suggests that the signalling pathways underlying EMT are CFTR mutation-dependent. The gene discussed is CFTR; the disease is cystic fibrosis.