In type 1 diabetes, curcumin, as a heme oxygenase-1 (HO-1) inducer, improved blood glucose levels (27.5% lower) and insulin secretion (66.67% higher) in diabetic rats, as well as regulating blood lipids and attenuating lipid peroxidation damage in the pancreas and liver (Abdel Aziz et al., 2012). This evidence concerns the gene HMOX1 and type 1 diabetes mellitus.