Studies have shown that curcumin can intervene in the occurrence and development of a variety of chronic inflammatory diseases by regulating key inflammatory signaling pathways such as NF-κB, MAPK, and JAK-STAT, such as rheumatoid arthritis, inflammatory bowel disease and neurodegeneration (Naksuriya et al., 2014). The gene discussed is NFKB1; the disease is inflammatory bowel disease.