As evidenced, specific genes that may be descriptive of a broader cell type such as GRIN3A or HTR7 for macrophages are generally upregulated in samples with estimated higher macrophages, while other genes that may be differentially expressed in a cancer type due to underlying genomic events in the tumor such as hypermutation or genomic alteration can cause significant differences to appear. Here, GRIN3A is linked to neoplasm.