Immunohistochemical analysis with anti-PRSS3, anti-PRSS22, and anti-CEA antibodies applied to H&E(+) LNs demonstrated that a fraction of the tumor cells in the LNs, displayed positive staining for both PRSS3 (Figures 4A, B, D, E) and PRSS22 (Figures 4G, H, J, K). Here, PRSS3 is linked to neoplasm.