LGR5 and colonic neoplasm: We previously studied mRNA biomarkers that correlated with poor prognosis in colon cancer (CC) patients, such as leucine-rich repeat-containing G protein-coupled receptors 5 and 6 (LGR5 and LGR6), as well as C-X-C motif chemokine ligands 16 and 17 (CXCL16 and CXCL17) (8–11).