ColoNode, a novel prognostic tool, was found recently to exceed traditional histopathology in predicting colon cancer relapse and risk stratification by integrating mRNA expression analysis of five biomarkers [carcinoembryonic antigen cell adhesion molecule-5 (CEACAM5), kallikrein related peptidase-6 (KLK6), mucin-2 (MUC2), periostin (POSTN), solute carrier family 35 member D3 (SLC35D3)] in half of the lymph node volume (12). Here, KLK6 is linked to colonic neoplasm.