In esophageal and gastric cancers, targets such as HER2 (NCT02713984), EGFR, CEA (NCT02349724), MSLN (NCT03747965), CLDN18.2 (NCT05472857), and NKG2D have shown effective antitumor effects in preclinical and early clinical trials. The gene discussed is EGFR; the disease is gastric cancer.