In esophageal and gastric cancers, targets such as HER2 (NCT02713984), EGFR, CEA (NCT02349724), MSLN (NCT03747965), CLDN18.2 (NCT05472857), and NKG2D have shown effective antitumor effects in preclinical and early clinical trials. Here, KLRK1 is linked to gastric cancer.