Numerous studies conducted on animals or humans have demonstrated that elevated triglyceride levels, impaired glucose metabolism, and increased BMI in CKD are linked to the activation of the renin–angiotensin system, the β-catenin signaling pathway, dysbiosis of the intestinal microbiota, abnormal long non-coding RNAs (LncRNAs), and various metabolic disorders. The gene discussed is REN; the disease is chronic kidney disease.