PLK4 and hepatocellular carcinoma: Using TCGA-LIHC data, we discovered 24 differentially expressed genes with prognostic relevance in LIHC, including several validated disease regulators: Elevated CDK2 expression promotes LIHC proliferation [31], TTK inhibitors increase LIHC radiosensitivity via p21 signaling [32], and PLK4 overexpression correlates with adverse HCC prognosis [33].