The parameters which best fit the data (Figure 4B, higher values in yellow correspond to better fit), corresponded to maximum effect from TMZ dosing between CT2 and CT8, agreeing with prior findings that maximum TMZ-induced tumor cell death occurs at CT4, around the time when daily BMAL1 and MGMT protein levels begin to decrease, but not when they reach their lowest abundance. This evidence concerns the gene BMAL1 and neoplasm.