In exocrine pancreas of obese organ donors, E-cadherin+ Chromogranin− epithelium showed higher expression of the pro-inflammatory adhesion molecule Galectin-3 (Gal-3), which is known to be upregulated in obesity, chronic pancreatitis and pancreatic cancer57–62(Figure 6B). The gene discussed is LGALS3; the disease is obesity due to melanocortin 4 receptor deficiency.