The pancreatic TRM DEGs that were increased in obesity showed the greatest enrichment in pathways related to interferon response (e.g. STAT3, MX1, MX2, IFI30), inflammation (e.g. CSF3, ICAM1, CXCR6) and T-cell effector function (e.g. PRF1, GZMB) (Figure 3E, Table S4)36. The gene discussed is GZMB; the disease is obesity due to melanocortin 4 receptor deficiency.