APOE and Alzheimer disease: In this study, we examined a cohort of cognitively unimpaired older individuals from the general population with the aim to: (1) identify specific cortical and subcortical grey matter patterns; (2) investigate their associations with clinical and brain MRI variables, APOE status and CSF AD biomarkers; and (3) assess how these subgroups evolve over a 5-year follow-up.