FMR1 and fragile X syndrome: To estimate the role of downregulated autophagicprotein degradation in synaptic defects of FXS, we compared proteins increased inhippocampus of Fmr1 KO(Fmr1−/y) micevs. WT mice with proteins increased in hippocampus of WT mice whenautophagy was inhibited by a pharmacological inhibitor, Chloroquine (CQ)52.