In pursuit of this, we interrogated human melanoma cells and found that doxycycline-induced, ectopically expressed ARF6-GTP, in the form of ARF6Q67L (Fig. S1a), or adenoviral delivered ARF6Q67L, augmented endogenous BRAFV600E expression in human melanoma cells (Fig. 1c–d). The gene discussed is ARF6; the disease is melanoma.