Consistent with genetic activation of ARF6, pharmacological activation of ARF6 with QS11 (Fig. S1b), an inhibitor of ARF GTPase Activating Protein 131, increased BRAFV600E protein expression in human melanoma, colorectal carcinoma and glioma cell lines (Fig. 1e, S1c). The gene discussed is ARF6; the disease is glioma.