The Th17 CCL20 cluster in LS and LS-CRC groups exhibited upregulation of genes associated with antigen presentation (HLA-DQB1, HLA-DRB1, TRBV18), inflammatory signaling (IL22, GPR25, ALPK2, HDGFL3, ARL17B), transcriptional control and differentiation (SOX5, LINC02384, MIR181A1HG), and cellular stress protection (HSPA1A, HSPA1B) compared with CON (Figure S6B; Table S6). Here, HDGFL3 is linked to colorectal carcinoma.