Recent advances in single-cell transcriptomics, combined with studies in postmortem human PD and preclinical mouse models, revealed that the Aldh1a1+/Anxa1+ subpopulation is the most susceptible dopamine neuron subtype in PD.11–13,16 Our data indicate that this ventral-biased subtype displays elevated expression of LRRK2 protein, further underscoring its unique properties relevant to PD pathophysiology. Here, ALDH1A1 is linked to Parkinson disease.