Of note, Kdm8 or KDM8 knockdown in murine and human PDA cell lines, respectively, reduced the expression of the rate-limiting enzyme Nsdhl or NSDHL for cholesterol biosynthesis63, which may explain the loss of glandular morphology in Kdm8-depleted PDA cells (Figures S3B). Here, NSDHL is linked to Patent ductus arteriosus.