Using single nuclei transcriptomes isolated from a separate PDA cohort73, we found a striking correlation between the classical-like and KDM8-induced gene signatures in malignant cells, thus eliminating the possibility that the correlations in the bulk RNA-Seq datasets were driven by non-malignant cell types in tumors (Figures S3L and S3M). Here, KDM8 is linked to Patent ductus arteriosus.