We observed significant enrichment of insulin-binding B cells amongst T-bet+ CD11c+ and CD11b+ CD11c+ populations in the pancreas and pancreatic lymph nodes of T1D-prone VH125SD.NOD mice, with T cell loss of Bcl6 chiefly impacting skewing to the CD11b+ CD11c+ subset. The gene discussed is ITGAM; the disease is type 1 diabetes mellitus.