HUWE1 and cancer: None of the previously reported nuclear interactors of MCL1 were identified with a probability SP > 0.8, although we confidently identified MCL1 itself, MCL1’s known partner E3 ligase Mule aka HUWE1,55, 56 and one known cytoplasmic MCL1 interactor (translationally-controlled tumor protein TPT1 aka p23).57, 58 In aggregate, our data do not support previous reports on the specific interaction of nuclear MCL1 with DNA damage or cell cycle-regulating proteins in cancer cells.