Considering that DUX4 expression is detrimental to muscle development and often toxic to somatic cells (Bosnakovski et al., 2017; Bosnakovski et al., 2018; Kowaljow et al., 2007; Mitsuhashi et al., 2013; Rickard et al., 2015; Tassin et al., 2013; Wallace et al., 2011; Wuebbles et al., 2010; Yao et al., 2014), this suggests the possibility that, in FSHD, aberrant expression of DUX4 in the pericyte developmental lineage might adversely impact the pericyte cell population and/or function, potentially contributing to FSHD pathophysiology over time. This evidence concerns the gene DUX4 and facioscapulohumeral muscular dystrophy.