Compared to other renal cell types, ADPKD fibroblast cluster was the major source of 13 collagen subtypes, including COL1A1, COL1A2, COL3A1, COL4A1, COL4A2, COL5A1, COL5A2, COL6A2, COL6A3, COL12A1, COL14A1, COL15A1, and COL16A1 (Fig 1A). Here, COL6A3 is linked to autosomal dominant polycystic kidney disease.