Several matricellular proteins, including osteopontin (SPP1), cellular communication network factors (CCN1 and CCN2), osteonectin (SPARC), fibulin-1 (FBLN1), FBLN5 and SERPINE1 exhibited higher expression in fibroblasts clusters from ADPKD kidneys compared to normal control kidneys (Fig 1D). This evidence concerns the gene SPP1 and autosomal dominant polycystic kidney disease.