TNFSF11 and rheumatoid arthritis: At the same time, RA-FLSs inhibits the secretion of osteoprotegerin (OPG), disrupts the RANKL/OPG balance, further promotes OC production and inhibits the bone repair effect, and inhibits the formation of osteoblasts under inflammatory conditions, which is the core effector cell of RA bone and joint destruction and the “central amplifier” in the process of bone destruction (50, 52, 56).