These findings suggested significant associations between gut microbiota composition and clinical biochemical markers in HBV-related liver cirrhosis patients, reminding us that changes of the gut microbial composition could predicting HBV-related liver cirrhosis in terms of clinical indicators such as thrombocyte, thrombin time, albumin, prothrombin time, γ-glutamyl transferase, AST, ALT, TC and TG. The gene discussed is GPT; the disease is cirrhosis of liver.