F2 and cirrhosis of liver: These findings suggested significant associations between gut microbiota composition and clinical biochemical markers in HBV-related liver cirrhosis patients, reminding us that changes of the gut microbial composition could predicting HBV-related liver cirrhosis in terms of clinical indicators such as thrombocyte, thrombin time, albumin, prothrombin time, γ-glutamyl transferase, AST, ALT, TC and TG.