Mutations in MED25 are associated with Basel-Vanagaite-Smirin-Yosef Syndrome (BVSYS) and Intellectual disability (ID) (Figueiredo et al., 2015; Ba et al., 2015; Mai et al., 2021; Haynes et al., 2020; Nair et al., 2019). The gene discussed is MED25; the disease is congenital cataract-microcephaly-nevus flammeus simplex-severe intellectual disability syndrome.