SPTA1 and histiocytic sarcoma: Additionally, a review (12) of all relevant literature published between 2000 and 2020 on Chinese HS patients, which covered genetic findings and clinical data, listed a total of 158 variants, with pathogenic gene mutation frequencies as follows: ANK1 (46%), SPTB (42%), SLC4A1 (11%), and SPTA1 (1%).