Studies by Aggarwal (15) and Tole (9) et al. indicate that the clinical manifestations of ANK1-HS patients are very similar to those of SPTB-HS, and that the type or location of a single gene mutation cannot be used as a basis for predicting the severity of clinical manifestations (such as anemia, jaundice, etc.)in these patients. This evidence concerns the gene ANK1 and anemia (phenotype).