LGR5 and cancer: Further studies demonstrated that infection of antrum-derived gastric organoid cells with H. pylori led to an increase in the expression of the stem cell marker leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5), suggesting that H. pylori infection may influence stem cell dynamics, potentially contributing to epithelial repair processes or, conversely, to pathological conditions such as cancer initiation (Nascakova et al., 2024).