For instance, SARS-CoV-2 causes RAAS (renin-angiotensin-aldosterone system) pathway dysregulation, induces degradation of the tumor repressor retinoblastoma protein, via nsp15 and P53 via nsp3, affects cell cycle through among others nsp7, interferes with DNA methylation through NSP8, and generates reactive oxygen species (ROS), all common pathways involved in oncogenesis, making a link to cancer plausible (Criterion 9) (Jahankhani et al., 2023). This evidence concerns the gene TP53 and cancer.