CD4 and Hodgkins lymphoma: For example, the attributable fraction of EBV-associated Hodgkin lymphoma in the general population is 20-50%, but in HIV-infected patients, 75%-100% of Hodgkin lymphoma is attributable to EBV, possibly due to aberrant CD4 T-cell responses to EBV infection (Carbone and Gloghini, 2018; Shindiapina et al., 2020; Navarro et al., 2021).