Another study showed that in the progression of AP in mouse models, acinar cells could express DC-SIGN, which could trigger the differentiation of naive CD4+ T cells into CD4+/IFN-γ+ Th1 and CD4+/IL-17A+ Th17 cells (the functions of Th17 and other T cells types will be discussed below) (105). This evidence concerns the gene CD4 and alkaline phosphatase measurement.