The enzyme encoded by the AKR1B1 gene is mainly responsible for reducing a variety of aldehydes to their corresponding alcohols, and studies have indicated that Linarin has anti-inflammatory, antioxidant, and anti-apoptotic effects in osteoarthritis, and Linarin reduces the intensity of the inflammatory response by inhibiting endoplasmic reticulum stress and further inhibiting AKR1B1 (38). The gene discussed is AKR1B1; the disease is osteoarthritis.