To evaluate this in a tumor-specific setting, CD8+ T cells pre-activated with anti-CD3/anti-SLAMF7 or anti-CD3/isotype coupled microspheres were co-cultured with CSF-1-matured, NY-ESO-1–pulsed APCs in the presence or absence of PD-1/PD-L1 blockade using specific ab. The gene discussed is CD8A; the disease is neoplasm.