And Panx1 have both promoting and restricting tumor functions in colon cancer (Fierro-Arenas et al., 2024; Derangère et al., 2014) and malignant glioma cells (Lai et al., 2007; Wei L. et al., 2015; Wei et al., 2016). Here, PANX1 is linked to malignant colon neoplasm.