In addition, they proposed that Panx2 protein levels were higher in testicular cancer-resistant cell lines, and downregulation of Panx2 led to decreased caspase-3 and BCL2-associated X protein (BAX) expression, and increased B-cell lymphoma 2 (BCL2) expression, enhanced DDP-induced apoptosis in testicular cancer I-10 cells (Yao et al., 2020), which argued that patients with low Panx2 expression might be more sensitive to the therapeutic effect of DDP. This evidence concerns the gene CASP3 and testicular cancer.