PANX2 and testicular cancer: In addition, they proposed that Panx2 protein levels were higher in testicular cancer-resistant cell lines, and downregulation of Panx2 led to decreased caspase-3 and BCL2-associated X protein (BAX) expression, and increased B-cell lymphoma 2 (BCL2) expression, enhanced DDP-induced apoptosis in testicular cancer I-10 cells (Yao et al., 2020), which argued that patients with low Panx2 expression might be more sensitive to the therapeutic effect of DDP.