In PDAC, as down-regulator of mitochondrial protein Ubiquinol-Cytochrome C Reductase Core Protein 1 (UQCRC1), Panx1 releases ATP extracellularly, which functions on Purinergic Receptor P2Y 2 (P2Y2) via autocrine action, activating RTK-PI3K-AKT signaling pathway and thus promoting cancer cell proliferation (Wang et al., 2020). Here, AKT1 is linked to cancer.