Clinical data reveal decreased Panx1 mRNA in peripheral blood mononuclear cells (PBMC) of pediatric asthma patients, while CD4+ T cell-specific Panx1 KO mice showed exacerbated House Dust Mite (HDM)-induced airway inflammation reversible upon Panx1 reconstitution (Medina et al., 2021). Here, PANX1 is linked to asthma.