Panx1 promotes tumor metastatic progression in multiple epithelial-derived tumors including breast, gastric, hepatocellular, testicular, melanoma, and cSCC (O'Donnell, 2024; Freeman et al., 2019; Sayedyahossein et al., 2021; Furlow et al., 2015; Jalaleddine et al., 2019; Ying et al., 2021; Shi et al., 2019). The gene discussed is PANX1; the disease is skin squamous cell carcinoma.