Increased TLR2 production has been identified in papulopustular rosacea, which is strongly associated with Demodex presence (12); changes in production and distribution of TLR2 are also seen in atopic dermatitis, contact dermatitis and psoriasis (83), which are currently rarely ascribed to Demodex. However, Demodex may secrete bioactive molecules that affect TLR2 receptor expression (74) as a means of countering this phenomenon. This evidence concerns the gene TLR2 and psoriasis.