PRSS2 and hypertensive disorder: Because GTEx data reflect healthy “baseline” expression, these shifts upregulation of pancreas and kidney enriched genes (SPINK1, PRSS2, ANPEP) and downregulation of adrenal or metabolic tissue–enriched genes (QPCT, SCD5), highlight how T2DM and HTN jointly perturb organ-specific pathways (exocrine stress, oxidative balance, lipid processing and vascular remodeling).