In the T2DM-specific network (ME3), GNB1 emerged as the most connected hub, consistent with its established role in transducing G protein-coupled receptor (GPCR) signals that regulate insulin secretion, glucose metabolism, and inflammatory pathways (Saddala et al., 2018; Murakami et al., 2019). Here, GNB1 is linked to type 2 diabetes mellitus.