Notably, the presence of other highly connected genes such as PDCD11 (26 interactions), KRR1 (26), CYP2E1 (24), MRPL13 (24), PLCG2 (22 interactions), and RPS27 (22) further suggest the involvement of ribosome biogenesis, mitochondrial function, xenobiotic metabolism, and phosphoinositide signaling, as key contributors to T2DM pathophysiology. This evidence concerns the gene PLCG2 and type 2 diabetes mellitus.