In the HTN-specific network (ME7), MAPK1 was identified as the topological hub with the highest degree of connectivity, followed by BUB1B, CDK1, and RPS6. The prominence of MAPK1, a key effector of the MAPK/ERK pathway, highlights its relevance in hypertensive pathophysiology, where it modulates vascular smooth muscle cell proliferation, endothelial function, and oxidative stress responses. This evidence concerns the gene RPS6 and hypertensive disorder.