The oxidative stress-related genes found in ME3 support this model, as hyperglycemia and lipotoxicity are known to increase reactive oxygen species (ROS) production, which activates NF-κB and upregulates inflammatory cytokines (Keane et al., 2015; Li et al., 2016; Vilas-Boas et al., 2021; Mukai et al., 2022). The gene discussed is NFKB1; the disease is Hyperglycemia.