In HTN, a distinct TF activity profile emerged, with prominent activation of HNF4A, MYC, AR, and NFIC factors implicated in vascular remodeling, endothelial proliferation, and transcriptional reprogramming of metabolic and inflammatory genes (Gao et al., 2017; Norambuena-Soto et al., 2020; Wan et al., 2022). Here, NFIC is linked to hypertensive disorder.