There are mainly nine classes of DUBs, including ubiquitin-specific proteases (USPs), ovarian tumor domain proteases (OTUs), ubiquitin C-terminal hydrolases (UCHs), Machado-Joseph domain (or Josephin domain)-containing proteins (MJDs), JAMM/MPN domain metalloproteases (JAMMs), Zinc finger with UFM1-specific peptidase domain protein (ZUFSP/ZUP1), MIU-containing novel DUB family (MINDY), monocyte chemotactic protein-induced protein (MCPIP) and permuted papain fold peptidase of dsDNA viruses and eukaryotes (PPPDE) (Ge, 2022; Ren, 2023). Here, ZUP1 is linked to neoplasm.