Some previous studies have demonstrated the anti-colitis effects of quercetin, and it is believed that protective benefits of quercetin stem from its powerful anti-inflammatory properties, which involves the direct suppression of the NLR family pyrin domain containing 3 (NLRP3) inflammasome (Wu et al., 2024), the nuclear factor kappa B (NF-κB) signaling pathway (Li et al., 2019), the sirtuin 1 (SIRT1)/Akt pathway (Cui et al., 2022), and other anti-inflammatory pathways (Liu et al., 2025). This evidence concerns the gene SIRT1 and colitis.