Curcumin, a polyphenol from turmeric, disrupts cancer cell formation and tumor development by promoting apoptosis via a p53-dependent mechanism, while also suppressing angiogenesis through nuclear factor-κB (NF-κB) and AP-1 inhibition and downregulating vascular endothelial growth factor (VEGF) and basic fibroblast growth factor. The gene discussed is VEGFA; the disease is neoplasm.