There was a significant increase in MS risk as indicated by IVW (OR = 1.39; 95% CI = 1.23, 1.58; P = 1.42e-07), IVW (Mod.2nd) (OR = 1.39; 95% CI = 1.28, 1.51; P = 2.31e-15), MR-Egger (OR = 1.39; 95% CI = 1.01, 1.92; P = 4.51e-02), MR-GRIP (OR = 1.41; 95% CI = 1.21, 1.65; P = 1.80e-05), MR-LASSO (OR = 1.39; 95% CI = 1.24, 1.56; P < 0.00001), MR-PRESSO (OR = 1.39; 95% CI = 1.28, 1.51; P = 3.79e-14), MR-RAPS (OR = 1.39; 95% CI = 1.24, 1.56; P = 2.66e-08), GSMR (OR = 1.38; 95% CI = 1.23, 1.55; P = 3.35e-08), and the weighted median method (OR = 1.41; 95% CI = 1.14, 1.74; P = 1.41e-03). This evidence concerns the gene GRIP1 and myeloid sarcoma.