Diagnostic workup revealed positive 3-hydroxy-3-methylglutaryl-CoA reductase antibodies (HMGCR Ab), magnetic resonance imaging (MRI) findings consistent with inflammatory myopathy, and a muscle biopsy demonstrating scattered necrotic and regenerating fibers, characteristic of immune-mediated necrotizing myopathy (IMNM). The gene discussed is HMGCR; the disease is myopathy.