1. SMG1 likely reduces inflammation (Roberts et al. 2013) but inhibition of SMG1 increases T‐cell and cytokine activity (Vendramin et al. 2024). Other Serine/threonine‐protein kinase PAK 3‐like and 1 differentiated across elevation (Cassin‐Sackett, Callicrate, and Fleischer 2019); PAK3 associated with survivorship from malaria in experimentally infected 'amakihi (Atkinson et al. in review), and SGK3 differentially expressed in groups of experimentally infected 'amakihi (Paxton et al. 2023). Here, SMG1 is linked to malaria.