IL6 and sleep disorder: Evidence has already suggested that acupuncture exerts its effects through 3 primary pathways: (1) neuroendocrine regulation via the hypothalamic–pituitary-ovarian (HPO) axis to stabilize hormonal levels (7); (2) neuromodulation, enhancing central neurotransmitters such as serotonin and γ-aminobutyric acid (GABA), which contribute to improved mood and sleep quality (8); (3) immunomodulation, reducing inflammatory cytokines like interleukin-6 (IL-6), which are linked to neuroendocrine dysfunction and sleep disturbances (9).