According to the STRAW +10 criteria, it is characterized by a gradual decline in ovarian function and is divided into 2 substages: early perimenopause (Stage −2), marked by increased menstrual cycle variability and elevated early follicular phase FSH, and late perimenopause (Stage −1), defined by amenorrhea lasting≥60 days, significantly elevated FSH levels, and markedly reduced anti-Müllerian hormone (AMH) and antral follicle count (AFC) (1). The gene discussed is AMH; the disease is amenorrhea.